Vascular endothelial cell-secreted exosomes facilitate osteoarthritis pathogenesis by promoting chondrocyte apoptosis
نویسندگان
چکیده
منابع مشابه
Chondrocyte Apoptosis in the Pathogenesis of Osteoarthritis
Apoptosis is a highly-regulated, active process of cell death involved in development, homeostasis and aging. Dysregulation of apoptosis leads to pathological states, such as cancer, developmental anomalies and degenerative diseases. Osteoarthritis (OA), the most common chronic joint disease in the elderly population, is characterized by progressive destruction of articular cartilage, resulting...
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Procyanidins are a family of plant metabolites that have been suggested to mitigate osteoarthritis pathogenesis in mice. However, the underlying mechanism is largely unknown. This study aimed to determine whether procyanidins mitigate traumatic injury-induced osteoarthritis (OA) disease progression, and whether procyanidins exert a chondroprotective effect by, at least in part, suppressing vasc...
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Osteoarthritis (OA) is the most prevalent degenerative joint disease with multifactorial etiology caused by risk factors such as ageing, obesity and trauma. Previously, it was reported that the inhibition of microRNA-34a (miR-34a) may reduce rat chondrocyte apoptosis induced by IL-1β, whereas the molecular mechanism and the role of miR-34a in human chondrocyte as well as in OA progression remai...
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Endothelial cells incorporate 35SO4 into a class of glycoproteins which are released from the cell layer into the culture medium. The incorporated 35SO4 was localized on intact oligosaccharide chains which were released from the protein either chemically by hydrazinolysis or enzymatically by a peptide: N-glycosidase activity; thus these 35S-oligosaccharides are presumably N-glycosidically linke...
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ژورنال
عنوان ژورنال: Aging
سال: 2021
ISSN: 1945-4589
DOI: 10.18632/aging.202506